CCRR: Complex Chromosomal Rearrangements Resolver

    CTLPScanner aims to accurately identify chromothripsis-like events and regions in genome.For an automatic identification of CTLP, a scan-statistic likelihood ratio based on the Poisson model was employed. It is commonly used to detect clusters of events in time and/or space and to determine their statistical significance. For each chromosome, the algorithm uses a series of sliding windows to identify the genomic region with the highest likelihood ratio as the CTLP candidate. This algorithm can automatically adjust the size of “scan window” to find the reasonable region of chromothripsis.The current version of CTLPSanner now supports copy number information obtained from multiple modal species and various sequencing methods.